Gastroesophageal reflux (GER) is defined as the retrograde movement of gastric contents
into the oesophagus; it is a physiologic process that occurs in everyone, young
and old, particularly after meals. GER often mimics food allergy in infancy (usually
cows milk), but occasionally it can be caused by food allergy.
Classification of GER:
The most useful classification of GER divides the spectrum of reflux into 3 caterories:
Functional GER represents a
benign condition that does not require evaluation or treatment. This does not cause
inflammation and does not lead to any long term complication. This category ranges
from passage of refluxate into the lower oesophagus to frequent regurgitation of
gastric contents out of the mouth typically seen in infants.
GERD, in contrast, requires
treatment. This class represents GER with associated complications, either
( e.g., failure to thrive, anaemia, oesophagitis, Barretts
oesophagus) or atypical (e.g., wheezing, apnea,
pneumonia, chronic sinusitis).
Secondary GER is caused by
some underlying condition, which causes retrograde movement of gastric contents.
The appropriate treatment usually involves addressing the underlying cause directly
(e.g., pyloric stenosis), or to obtain control of GER (e.g., neurologic impairment).
Other conditions associated with secondary GER include food allergy,
infection and nasogastric tubes, and metabolic defects.
GER in neurologically abnormal children
Children with neurological disability often suffer from feeding difficulties, vomiting,
failure to thrive, recurrent chest infections and irritability, and such symptoms
are often acceptesd as part of the disability. Abrahams and Burkitt in 1970 first
reported the association of GER and cerebral palsy. They found reflux in 75% of
cases of cerebral palsy.
Prevalence of GER depends on age. Approximately 50% of 0
3 month olds have at least 1 episode of regurgitation per day. This increases to
a peak of 67% of infants at 4 months of age. The prevalence drops to approximately
5% of 10 12 month olds. The sharpest drop occurs around 6 months of age and
is associated with the development of improved neuromuscular control
and the infant sitting up. GER and reflux associated complications are more common
in neurologically impaired children and premature infants.
Prognosis of GER in Infants:
GER spontaneously resolves in 81% of infants by age 18 months.
Causes and risk factors for GERD
GERD is caused by a weak oesophageal sphincter that is present at birth or that
develops later in life. A hiatal hernia can also cause GERD. Hiatal Hernia is a
condition in which the stomach pushes up into the diaphragm muscle. When this happens,
the oesophageal sphincter does not work properly. As a result, the fluid can easily
leak back into the oesophagus.
Factors that make GERD worse include:
- Being overweight or obese
- Being pregnant
- Drinking alcohol or caffeine
- Drinking carbonated beverages or fruit juice
- Eating chocolate or peppermint
- Eating fatty or spicy foods
- Eating large meals
- Lying down or bending over after a meal
Medications, such as aspirin and other anti-inflammatory
- Smoking or using tobacco products
Symptoms of GERD in adults
The most common symptom of GERD is
It is perceived as a substernal burning sensation, and usually occurs after
meals or when reclining at bedtime.
Regurgitation is a bitter or
acidic taste in the mouth caused by gastric contents refluxed up into the oesophagus.
Regurgitation is differentiated from vomiting by the lack of abdominal wall and
Besides the discomfort of heartburn, reflux
results in symptoms of oesophageal inflammation, such as odynophagia
(pain on swallowing) and dysphagia (difficult swallowing).
Chest pain caused by reflux
may be sharp or dull and may radiate widely into the neck, arms, or back. The pain
is thought to be caused by either the stimulation of chemoreceptors, or by the distention
of the esophagus, but may be caused by cardiac (microvascular angina) chest pain
precipitated by reflux. It can be difficult to differentiate cardiac chest pain
The acid reflux may also cause pulmonary symptoms such as coughing (
3rd commonest cause of chronic cough after PND and asthma),
wheezing, asthma. Most studies show that 45% to 65% of adult asthmatics
have GERD. Pulmonary symptoms may be caused directly by the aspiration of acid in
the bronchial tree, but may also be caused indirectly by the acidification of the
oesophagus, which causes vagally induced bronchoconstriction.
Aspiration pnuemonia, and interstitial fibrosis can also be caused by GERD.
Oral symptoms such as tooth
decay, gingivitis, halitosis (bad breath), and waterbrash (the spontaneous appearance
of high volumes of saliva in the mouth, and is caused by vagally mediated reflex
initiated by acid in the oesophagus)
Throat symptoms such as soreness,
laryngitis and hoarseness are also symptoms of GERD.
Earache may result from acid
damage to the oropharynx.
Investigations for GER
Lower oesophageal pH monitoring
Extended oesophageal pH monitoring over 18 24 hours is now well established
as the gold standard for documenting acid GER, providing more physiological
and accurate information about reflux as a dynamic phenomenon than barium studies.
Barium studies are requested if an anatomical abnormality is suspected, such as
hiatus hernia, oesophageal stricture, or gastric outlet obstruction. Although used
historically for diagnosis, barium studies should not be used to diagnose or quantify
GER, as gastro-oesophageal dynamics are only examined over a very short period of
This involves continuous imaging after feeding the patient a technetium 99m-radiolabelled
meal. It is most commonly used to evaluate gastric emptying. It will also show non-acid
reflux, and it is also specific (but not sensitive) for the detection of aspiration
of gastric contents.
Direct Laryngoscopy and Bronchoscopy enables a definite diagnosis of oesophagitis
to be made, both macroscopically and histologically. Oesophageal strictures, hiatus
hernia, Barretts oesophagus, and other conditions which cause epigastric pain
or haematemesis may all be diagnosed.
DL & DB were performed on a large number of children known to have GERD, and
90% were noted to have at least 1 laryngotracheal abnormality.
Conservative Treatment of GERD
The baby should be positioned for sleep with the head raised to 30°
from the horizontal, best arranged by a folded blanket placed under the head end
of the mattress. The seated position worsens GER.
Avoid inappropriate feeding
of infants no huge feedings, and minimize air feedings/jostling during feeding.
- No feeds 2 hours before bedtime, when possible
Eliminate chocolate and caffeine from the diet,
and avoid tobacco exposure.
Thickening of feeds by adding 1 tablespoon
of dry rice cereal per ounce of milk formulae. This increases the caloric density
from 20 to 30kcal/ounce, decreases episodes of vomiting / regurgitation, increases
sleeping time, and decreases crying time. Alternatively, one may purchase prethickened
formula in powder form.
Small, frequent feeds Clearly indicated
in infants who consume excessively large meals; of questionable benefit in everybody
Medical Treatment of GERD
Prokinetic pharmacotherapy is the first line in young children (<2 years old)
because GER is primarily a problem of motility in this age group. They work by increasing
muscle tone at the lower end of the oesophagus, as well as hastening the passage
of food through the digestive system. Acid suppression is added when eosophagitis
Cisapride (prepulsid) was once
the first line medication in the treatment of GER in children. Several studies showed
it was more effective than other prokinetic agents in the treatment of GER. Cisapride
has minimal side effects with the exception of prolongation of the QT interval,
and there have been anecdotal reports of deadly cardiac arrhythmias. Known risk
factors for the development of these arrhythmias include preterm and newborn age,
heart disease and electrolyte abnormalities.
effects include nervousness, sleepiness, and dystonic reactions. These side effects
are more common in children and respond quickly to withdrawal of the drug and valium.
Antacids may be used for symptomtic
relief; they should not be given long term or mixed in with infant formula because
they can result in Aluminium toxicity and osteomalacia.
H-2 blockers (Cimetidine, Ranitidine,
Famotidine) are usually adequate to achieve acid suppression in young children and
Proton Pump Inhibitors (Omeprazole
is the only PPI that has been studied in children) usually required in cases of
severe chronic respiratory distress and neurologic disability. It should be given
with or just before the first meal of the day. In small children, the granules should
be delivered in an acidic medium, e.g., apple sauce or yogurt.
Surgery for GERD
Surgical treatment of GER (usually a Nissen fundoplication) may be inevitable if
full medical treatment has failed, or if there is an oesophageal stricture or Barretts
oesophagus at initial diagnosis. Such patients are best assessed jointly in a gastroenterological
medical /surgical clinic at an early stage to consider each childs problem
individually. Surgery should be preceded by a full functional and anatomical assessment
including review of barium studies, repeat oesophageal pH monitoring, motility and
gastric emptying studies to enable appropriate surgical procedures to be selected
after consultation with the parents. These may, for example, include a pyloroplasty
or insertion of a feeding gastrostomy. Complications of surgical treatment include
dumping, retching, intestinal obstruction, gas bloat, and recurrence